DAVID BALDING
Professor of Statistical Genetics,

University College London

POSTAL ADDRESS:

Institute of Genetics

University College London

2nd Floor, Kathleen Lonsdale Building

5 Gower Place London WC1E 6BT

Phone:

Desk +44 (0)20 3108 4005 internal 54005

Mobile +44 (0)75 9025 0432
e-mail: D.Balding@ucl.ac.uk

LINKS:

UGI

 

Sense about Science

Fair Pensions

           


NEW


SOME FUTURE EVENTS I AM ORGANISING


SOME COMMITTEES I AM A MEMBER OF


PEOPLE WORKING WITH ME:

 

PhD Students (see below for past PhD students):

Post-docs:

Charlotte Vignal (part-time, GSK, started Dec 2004)

Matt Nunes (EPSRC, started Aug 2008)

Jon White (part-time, NIAB, started April 07)

Adaikalavan Ramasamy (EU, started Jan 08) Joint with NHLI

Delilah Zabaneh (part-time, since 2006)

 

 

FORMER POSTDOCS

 


BOOKS:


 

RECENT PUBLICATIONS (since start 2008) AND PAPERS IN PRESS (earlier publications)


Astle W, Balding DJ, Population structure and cryptic relatedness in genetic association studies, to appear Statistical Science, 2010. Available at the “Future Papers” page of Statistical Science


Beaumont MA, Nielsen R, Robert C, Hey J, Gaggiotti O, Knowles L, Estoup A, Panchal M, Corander J, Hickerson M, Sisson SA, Fagundes N, Chikhi L, Beerli P, Vitalis R, Cornuet JM, Huelsenbeck J, Foll M, Yang Z, Rousset F, Balding D, Excoffier L. In defence of model-based inference in phylogeography. Mol Ecol. (11 Jan 2010) [Epub ahead of print] doi:10.1111/j.1365-294X.2009.04515.x


Krane DE, Bahn V, Balding D + 37 authors + Zabell S, Time for DNA Disclosure, letter to Science, 326(5960): 1631-1632, Dec 18 2009.


Eleftherohorinou H, Wright V, Hoggart C, Hartikainen A-L, Jarvelin M-R, Balding D, Coin L, Levin M, Pathway Analysis of GWAS Provides New Insights into Genetic Susceptibility to 3 Inflammatory Diseases. PLoS ONE 4(11): e8068, 2009. doi:10.1371/journal.pone.0008068


Stephens M, Balding DJ, Bayesian statistical methods for genetic association studies.  Nature Reviews Genetics 10: 681-690, Oct 2009. doi:10.1038/nrg2615


Lopes JS, Balding DJ, Beaumont MA, PopABC: a program to infer historical demographic parameters. Bioinformatics, 25(20): 2747-2749, 2009. doi:10.1093/bioinformatics/btp487


Zabaneh D, Chambers JC, Elliott P, Scott J, Balding DJ*, Kooner JS, Heritability and genetic correlations of insulin resistance and component phenotypes in Asian Indian families using a multivariate analysis.  Diabetologia, 52: 2585–2589, 2009. (* I supervised the work of DZ in writing this paper and was in effect senior author but this position was taken by someone who contributed less but had the power to block publication).  doi: 10.1007/s00125-009-1504-7


Chambers JC; Zhang W; Zabaneh D; Sehmi J; Jain P; McCarthy MI; Froguel P; Ruokonen A; Balding D; Jarvelin MR, Scott J, Elliott P, Kooner JS. Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type-2 diabetes amongst Indian Asians and European whites. Diabetes 5 2009. doi: 10.2337/db08-1805


Balding D, Ferrari PA, Fraiman R, Sued, M, Limit theorems for sequences of random trees, Test18(2): 302-315, 2009


Al-Bustan SA, Alkhalaf M, Al-Rashdan I, Al-Otaibi S, Al-Baker E, Balding D, Alnaqeeb MA, Apolipoprotein E, CI and B Gene Polymorphisms in a Sample of Patients with Coronary Heart Disease in the Kuwaiti Population, Medical Principles and Practice, 18(4): 294-299, 2009.


Balding DJ, DNA evidence: Interpretation of DNA profiles, in Encyclopedia of Forensic Science, Jamieson, A., Moenssens, A. (eds).  Wiley Chichester, UK, pp 2365-2376, 2009.


Balding DJ, Buckleton J, Interpreting low template DNA profiles, Forensic Science International: Genetics, 2009, doi: 10.1016/j.fsigen.2009.03.003


Meyre D, Delplanque J, Chevre J-C, Lecoeur C, Lobbens S + 31 authors + Balding D, Walley A, Dina C, Froguel P; Genome-wide association study for early-onset and morbid adult obesity identifies three new loci in European populations, Nature Genetics 41, 157–159, 2009. doi:10.1038/ng.301


Vignal C, Bansal AT, Balding DJ, Binks MH, Dickson MC, Montgomery DS, Wilson AG; Genetic Association of the Major Histocompatibility Complex With Rheumatoid Arthritis Implicates Two Non-DRB1 Loci, Arthritis & Rheumatism 60(1): 5362, 2009, DOI 10.1002/art.24138.


Su S-Y, White J, Balding DJ, Coin LJM; Inference of haplotypic phase and missing genotypes in polyploid organisms and variable copy number genomic regions, BMC Bioinformatics, 2008, 9:513.


Cornuet JM; Santos F; Beaumont MA; Robert CP; Marin JM; Balding DJ; Guillemaud T; Estoup A, Inferring population history with DIY ABC: a user-friendly approach to Approximate Bayesian Computation. Bioinformatics 24(23): 2713–2719, 2008; doi: 10.1093/bioinformatics/btn514


Chadeau-Hyam M, Hoggart CJ, O'Reilly PF, Whittaker JC, De Iorio M, Balding DJ, Simulation of realistic sequence-level data in populations and ascertained samples. BMC Bioinformatics 2008, 9:364.


Hoggart CJ, Whittaker JC, De Iorio M, Balding DJ, Simultaneous Analysis of all SNPs in Genome–Wide and Re–sequencing Association Studies, PLoS Genetics 4(7): e1000130, 2008. doi:10.1371/journal.pgen.1000130


O’Reilly PF, Birney E, Balding DJ, Confounding between recombination and selection, and the Ped/Pop method for detecting selection, Genome Research 18: 1304-1313, 2008, doi:10.1101/gr.067181.107


Chambers JC, Elliott P, Zabaneh D, Zhang W, Li Y, Froguel P, Balding D, Scott J, Kooner JS, Common genetic variation near the melanocortin-4 receptor gene is associated with waist circumference and insulin resistance, Nature Genetics 40, 716 – 718, 2008. doi:10.1038/ng.156


Calboli FC , Sampson J,  Fretwell N, Balding DJ, Population structure and inbreeding from pedigree analysis of purebred dogs, Genetics, 179(1): 593–601, 2008.  doi:10.1534/genetics.107.084954


Su SY, Balding DJ, Coin LJM, Disease Association Tests by Inferring Ancestral Haplotypes Using a Hidden Markov Model, Bioinformatics, 24: 972-978, 2008. doi:10.1093/bioinformatics/btn071


Hoggart CJ, Clark TG, De Iorio M, Whittaker JC, Balding DJ, Genome-Wide Significance for Dense SNP and Resequencing Data, Genetic Epidemiology, 32(2): 179-185, 2008.


Ioannidis JPA, Boffetta P, Little J, O’Brien TR, Uitterlinden AG, Vineis P, Balding DJ, Chokkalingam A, Dolan SM, Flanders WD, Higgins JPT, McCarthy MI, McDermott DH, Page GP, Rebbeck TR, Seminara D, Khoury MJ. Assessment of Cumulative Evidence on Genetic Associations: Interim Guidelines, Int. J. Epidem. 37(1):120-132, 2008  doi:10.1093/ije/dym159


SOFTWARE

The first two files contain code for calculating the LR, assuming 1 unknown and 2 unknown contributors, respectively.  The code in one or other of these must be executed first.  The remaining files provide the input data for various example analyses: Bates.R and CaseY.R contain the data for the analyses reported in the FSIG paper; Loco.R contains data from an example published by Gill et al 2007 (see comments in the file).  For CaseX, the two input files correspond to the full profile, assuming that major and minor components cannot be confidently distinguished, and the major component only.  None of the code has been rigorously tested: I plan to be conducting more tests in the near future.

 


PROFESSIONAL SOCIETIES:

JOURNALS:

Fellow of the Royal Statistical Society (member of Council 1999-2004).

AE of International Statistical Review (1999 – 2005)

Member of the International Statistical Institute.

AE of Biostatistics (2000 – 2004)

Member of the International Biometric Society (British & Irish President 2006-08)

AE of Human Genomics (2003 – 2006)

Member of the International Genetic Epidemiology Society

AE of Annals of Human Genetics (2004 – )


BACKGROUND:

 

PAST PhD STUDENTS:


CONSULTINGand SHORT COURSES

I offer a statistical consulting service, primarily to lawyers. Most often I advise on statistical aspects of the interpretation of DNA profile evidence, but I have also provided advice on a variety of other statistical aspects of forensic science, epidemiology and other fields.


PREVIOUS PUBLICATIONS

2007

·         Leschziner GD, Jorgensen AL, Andrew T, Williamson PR + 3 authors + Balding DJ + 3 authors + Johnson MR, Pirmohamed M, The association between polymorphisms in RLIP76 and drug response in epilepsy, Pharmacogenomics, 8(12): 1715-1722, 2007.

·         Hoggart CJ, Chadeau-Hyams M, Clark TG, Lampariello R, De Iorio M, Whittaker JC, Balding DJ, Sequence-level population simulations over large genomic regions, Genetics 177: 1725–1731, 2007 doi:10.1534/genetics.106.069088

·         Clark TG, Andrew T, Cooper GM, Marguiles EH, Mullikin JC, Balding DJ. Functional constraint and small insertions and deletions in the ENCODE regions of the human genome Genome Biology, 8:R180, 2007  doi:10.1186/gb-2007-8-9-r180

·         Graffelman J; Balding DJ; Gonzalez A; Bertranpetit J.  Variation in Estimated Recombination Rates across Human Populations, Human Genetics, 122(3-4):301-310, 2007. doi:10.1007/s00439-007-0391-6

·         Leschziner GD; Andrew T; Leach JP; Chadwick D; Coffey AJ; Balding DJ; Bentley DR; Pirmohamed M; Johnson MR.  Common ABCB1 polymorphisms are not associated with multidrug resistance in epilepsy using a gene-wide tagging approach, Pharmacogenetics and Genomics 17: 217-220, 2007.

·         A genome-wide association study identifies novel risk loci for type 2 diabetes, Sladek R, Rocheleau G, Rung J, Dina C + 14 authors + Balding DJ, Meyre D, Polychronakos C, Froguel P, Nature 445: 881-885 2007. doi:10.1038/nature05616

·         Family-based association analysis with ordered categorical phenotypes, covariates and interactions, Baksh MF, Balding DJ, Vyse TJ, Whittaker JC, Genetic Epidemiology 31(1): 1-8, 2007. doi:10.1002/gepi.20183

 

2006

·         A tutorial on statistical methods for population association studies, Balding DJ, Nature Reviews Genetics 7: 781-791, 2006.  doi:10.1038/nrg1916

·         Clinical factors and ABCB1 polymorphisms in prediction of antiepileptic drug response: a prospective cohort study, Leschziner G, Jorgensen AL, Andrew T, Pirmohamed M, Williamson PR, Marson AG, Coffey AJ, Middleditch C, Rogers J, Bentley DR, Chadwick DW, Balding DJ, Johnson MR, Lancet Neurology 5: 668–76, 2006.

·         Exon sequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance, Leschzinger G, Zabaneh D, Pirmohamed M, Owen A, Rogers J, Coffey AJ, Balding DJ, Bentley DB & Johnson MR, Pharmacogenetics and Genomics, 16: 439-450, 2006.

·         Discrimination of half-siblings when maternal genotypes are known, LR Mayor & Balding DJ, Forensic Science International, 159(2-3): 141-147, 2006. doi:10.1016/j.forsciint.2005.07.007

·         Fine mapping of disease genes via haplotype clustering, ERB Waldron, JC Whittaker & Balding DJ, Genetic Epidemiology, 30: 170-179, 2006 Software

·         Logistic regression protects against population structure in genetic association studies, E Setakis, H Stirnadel & Balding DJ, Genome Research, 16: 290-296, 2006.

·         A family-based association test with a complex phenotype, covariates and interactions: assessing CRP and lupus, Baksh MF, Balding DJ, Vyse TJ & Whittaker JC, Annals of Human Genetics 70: 131-139, 2006.

2003-2005

·         Paternity index calculations when some individuals share commonancestry, KL Ayres & Balding DJ, Forensic Science International, 151(1): 101-103, 2005.

·         The impact of low-cost, genome-wide resequencing on association studies,Balding DJ, editorial for Human Genomics, 2(2): 79-80, 2005.

·         A question of identity, Balding DJ, Significance, 2(1): 20-23, March 2005.

·         Identifying adaptive genetic divergence amongpopulations from genome scans, MA Beaumont & DJB, Molecular Ecology, 13:969-980,2004. Software

·         Clustering of protein domains in the human genome, LRMayor, KP Fleming, A Müller, DJB & MJ Sternberg, Journal of MolecularBiology, 340(5): 991-1004,2004.

·         Little loss of information due to unknown phase forfine-scale LD mapping with SNP genotype data,  AP Morris, JC Whittaker & DJB, American Journal ofHuman Genetics, 74(5):945-953,2004.

·         Multipoint LD mapping narrows location interval andidentifies mutation heterogeneity, A. Morris, J. Whittaker, C-F Xu, LHosking& DJB, Proceedings of theNationalAcademy of Sciences of the USA 100(23):13442–13446,2003.

·         Gametic phase estimation over large genomic regionsusing an adaptive window approach, L. Excoffier, G. Laval & DJB, Human Genomics 1(1): 7-19, 2003.

·         Handbookof Statistical Genetics, 2nd edition, DJB, M.Bishop, & C. Cannings (Eds), Chichester:Wiley, 2003.

·         Inferences from DNA data: population histories,evolutionary processes, and forensic match probabilities, I.J. Wilson, M.E.Weale & DJB, read before the Royal Statistical Society, November 2002, Journalof the Royal Statistical Society A 166(2): 155-187, 2003 (see also discussion pp 188-202).

·         Likelihood-based inference for genetic correlationcoefficients, DJB, Theoretical Population Biology, 63(3): 221-230, 2003.

·         Chromosome-wide distribution of haplotype blocks andthe role of recombination hotspots, M.S. Phillips, R. Lawrence, R.Sachidanandam, A.P. Morris, DJB, + 29 authors + L.R. Cardon, NatureGenetics, 33:382-387,2003.

 

2000-2002

 

1997-1999

 

1994-1996

 

1985 - 1993


 
last updated 19 January  2010.